Acta Pharmaciae Indonesia : Acta Pharm Indo
Journal of Acta Pharmaciae Indonesia is a journal published twice a year by Pharmacy Department, Jenderal Soedirman University, Purwokerto with the Number of ISSN 2337-8433 and E-ISSN 2621-4520. Our journal discusses various pharmaceutical fields in terms of Pharmaceutics & Pharmaceutical Technology, Pharmaceutical Biology, Pharmaceutical Chemistry, and Pharmacology & Clinical Pharmacy.
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<![CDATA[Potensi interaksi obat nutrasetikal pada epilepsi anak ]]>
<![CDATA[Nialiana Endah Endriastuti]]>;
<![CDATA[Masita Wulandari Suryoputri]]>;
<![CDATA[Dewi Latifatul Ilma]]>;
<![CDATA[Tunggul Adi Purwonugroho]]>
<![CDATA[ Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo ]]>
Publisher : <![CDATA[Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia ]]>
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DOI: 10.20884/1.api.2022.10.1.4352
<![CDATA[Background: The trend of using nutraceuticals in Indonesia increases every year. This study aims to describe nutraceuticals consumed in pediatrics with epilepsy as additional antiepileptic therapy and analyze their potential drug interactions. Methods: This research was a cross-sectional study with total sampling method which was carried out in the period of June to July 2020. Inclusion criteria were children with epilepsy aged 0-17 years who were members of the Indonesian Epilepsy Community, had a doctor's diagnosis of epilepsy, received oral antiepileptic medication, and took nutraceutical products/food supplements. Data were analyzed descriptively based on data obtained through electronic data filling sheets and interviews. Results: There were 106 participants from the Indonesian Epilepsy Community in total, with 14 children (13.2 %) using nutraceutical supplements. They were male (n=8; 57.1%), 2-12 years old (n=10; 71.4%), and good nutritional status (n=10; 71.4%). Most nutraceuticals consumed were dietary supplements containing vitamins (n=10; 71.4%). Of the eight potential drug interactions identified, 25% (n=2) were significant interactions, and 75% (n=6) were minor interactions. The potential for major interactions occurred in administering nutraceutical products containing vitamin D with the antiepileptic drug phenytoin and phenobarbital. Conclusion: In this study, nutraceuticals and antiepileptic drugs had a little clinically meaningful interaction effect.]]>
<![CDATA[Antibacterial activity of Cassia alata stems ethanol extract against Staphylococcus aureus ]]>
<![CDATA[Ahmad Mahdi Mar'ie]]>;
<![CDATA[Irfan Zamzani]]>;
<![CDATA[Siti Nashihah]]>
<![CDATA[ Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo ]]>
Publisher : <![CDATA[Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia ]]>
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DOI: 10.20884/1.api.2022.10.1.5462
<![CDATA[Background: Cassia alata leaves, also known as petai cina or gelinggang in Indonesia, are commonly used to treat skin ailments. Objective: The purpose of this study is to test whether stem of C. alata has antibacterial activity against Staphylococcus aureus. Methods: C. alata stems were extracted using an ultrasound-assisted extraction method. For antibacterial activity, disc diffusion was used with extract concentrations of 25%, 50%, 75%, and 100%. Results: The inhibition zones of the ethanol extract of C. alata stems at 25%, 50%, and 75% concentrations were 17.6 mm, 21 mm, and 22.6 mm, respectively, with the highest inhibition zone at 100% concentration at 25 mm. Conclusion: The ethanolic extract of C. alata stems has a strong inhibitory effect on Staphylococcus aureus.]]>
<![CDATA[Drug utilization of N-Acetylcysteine in COVID-19 inpatients at Santa Elisabeth Hospital, Purwokerto ]]>
<![CDATA[Heny Ekowati]]>;
<![CDATA[Faradina Qorina Nadzif]]>;
<![CDATA[Masita Wulandari Suryoputri]]>
<![CDATA[ Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo ]]>
Publisher : <![CDATA[Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia ]]>
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DOI: 10.20884/1.api.2022.10.1.5776
<![CDATA[Background: COVID-19 is associated to an oxidant-antioxidant imbalance, which leads to inflammation and tissue damage. N-Acetylcysteine (NAC), in addition to being a mucolytic, has been shown to be an effective antioxidant in the therapy of COVID-19. Objective: The purpose of this study is to evaluate at the NAC usage profile in COVID-19 inpatients at Santa Elisabeth Hospital in Purwokerto. Methods: A descriptive observational design was used to perform the study. Retrospective data were obtained from medical records from July 2020 to July 2021. All patients who met the inclusion criteria were sampled using the total sampling technique. Results: NAC was commonly administered to COVID-19 inpatients who have a mild illness of the disease. The most common symptoms were cough and fever. Patients with mild and moderate severity were given NAC orally (600 mg 3 times a day) and intravenously (5 gram/day), respectively. The duration of NAC administration was in the range of 8-14 days. Conclusion: NAC was one of the therapies used at Santa Elisabeth Hospital Purwokerto for COVID-19 inpatients.]]>
<![CDATA[Solvent optimization in moringa leaves' flavonoids extraction using simplex lattice design ]]>
<![CDATA[Siti Muhsonah Oktaviana]]>;
<![CDATA[Wahida Hajrin]]>;
<![CDATA[Nisa Isneni Hanifa]]>
<![CDATA[ Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo ]]>
Publisher : <![CDATA[Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia ]]>
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DOI: 10.20884/1.api.2022.10.1.5271
<![CDATA[Background: Flavonoids found mainly as pharmacologically active natural ingredient of moringa (Moringa oleifera L.). Therefore, optimizing the solvent to maximize the levels of flavonoid components is needed. Objective: This study was conducted to determine the optimum solvent composition for extracting flavonoid compounds from moringa leaves using the simplex lattice design (SLD). Methods: Moringa leaves were extracted using the sonication method with five combinations of 96% ethanol and water as the solvent. The solvent composition was optimized using Design-Expert version 11 software. Moreover, UV-Vis spectrophotometry was used to screen and identify flavonoid content. Results: Flavonoids were detected in moringa extract. Using the F test, a valid SLD equation, y= 440,243(A) + 142,983(B) - 47,324(A)(B), was obtained. This equation shows that the solvent ethanol 96% : water (100:0) was the best solvent and produced the maximum amount of moringa flavonoid content, which was 440,2427 mg QE/g extract. Conclusion: The flavonoid content was directly proportional to the high composition of 96% ethanol.]]>
<![CDATA[Psidium guajava leaves extract decreased leukocytes and lymphocytes count in Complete Freund's Adjuvant-induced arthritis rats ]]>
<![CDATA[Hanif Nasiatul Baroroh]]>;
<![CDATA[Rupa Lesty]]>;
<![CDATA[Esti Dyah Utami]]>;
<![CDATA[Nur Ayunie Zulkepli]]>
<![CDATA[ Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo ]]>
Publisher : <![CDATA[Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia ]]>
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DOI: 10.20884/1.api.2022.10.1.5789
<![CDATA[Background: Psidium guajava is one of the herbal plants that has demonstrated antioxidant and anti-inflammatory properties. Objective: This study aimed to determine the effect of P. guajava leaves extract on leukocytes and lymphocytes in rats. Methods: Fifty rats were divided into five groups. Complete Freund’s Adjuvant (CFA) was employed to generate an animal model of arthritis. Group I (arthritis control) received CMC Na, group II (positive control) received dexamethasone 3 mg/kg BW, and groups III-V received 250, 500, and 750 mg/kg BW of the ethanol extract of P. guajava leaves orally. Total leukocyte counts were calculated on days 13 and 29, and on day 29, the histological joints were inspected. Results: The P. guajava leaves extract decreased the number of lymphocytes and total leukocytes. Before and after treatment, the group receiving doses of 250 mg/kg BW and 750 mg/kg BW of the extract showed a significant decrease in leukocytes. With treatment of 250, 500, and 750 mg/kg BW of P. guajava leaves ethanol extract, the lymphocyte count was also reduced. The P. guajava leaves extract at 750 mg/kg body weight showed the greatest effectiveness in suppressing leukocytes and lymphocytes. Conclusion: The extract of P. guajava leaves has the potential to be developed as an anti-inflammatory for arthritis.]]>
<![CDATA[Optimizing effervescent granules of blue pea (Clitoria ternatea L) flower ethanol extract as antioxidant ]]>
<![CDATA[Tuti Sri Suhesti]]>;
<![CDATA[Warsinah Warsinah]]>;
<![CDATA[Pitra Wulandari]]>
<![CDATA[ Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo ]]>
Publisher : <![CDATA[Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia ]]>
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DOI: 10.20884/1.api.2022.10.1.5803
<![CDATA[Background: Blue pea (Clitoria ternatea) contains secondary metabolites, including flavonoids, saponins, terpenoids, tannins, and anthocyanins which have antioxidant activity. Objective: This research aims to produce the effervescent granule preparations of the blue pea flower ethanol extract with the optimal concentrations of citric acid and tartaric acid. Methods: Blue pea flower was extracted using 70% ethanol. Effervescent granules were made using the wet granulation method in eight formulas containing citric acid and tartaric acid. The physical properties of granules were evaluated, including extract quality, flow rate, dissolution time, and pH. Results: The concentration of the mixed components of citric acid 48.65 mg and tartaric acid 576.30 mg was the most optimal combination of acid sources for effervescent granules of blue pea flower extract with a desirability value of 1,000. Conclusion: The variation in the concentration of citric acid and tartaric acid affected the effervescent granule preparation's flow rate, dissolution time, and pH.]]>
<![CDATA[Optimizing effervescent granules of butterfly pea (Clitoria ternatea L) flower ethanol extract as antioxidant ]]>
<![CDATA[Tuti Sri Suhesti]]>;
<![CDATA[Warsinah Warsinah]]>;
<![CDATA[Pitra Wulandari]]>
<![CDATA[ Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo ]]>
Publisher : <![CDATA[Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia ]]>
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DOI: 10.20884/1.api.2022.10.1.5803
<![CDATA[Background: Butterfly pea (Clitoria ternatea) contains secondary metabolites, including flavonoids, saponins, terpenoids, tannins, and anthocyanins which have antioxidant activity. Objective: This research aims to produce the effervescent granule preparations of the butterfly pea flower ethanol extract with the optimal concentrations of citric acid and tartaric acid. Methods: Butterfly pea flower was extracted using 70% ethanol. Effervescent granules were made using the wet granulation method in eight formulas containing citric acid and tartaric acid. The physical properties of granules were evaluated, including extract quality, flow rate, dissolution time, and pH. Results: The concentration of the mixed components of citric acid 48.65 mg and tartaric acid 576.30 mg was the most optimal combination of acid sources for effervescent granules of butterfly pea flower extract with a desirability value of 1,000. Conclusion: The variation in the concentration of citric acid and tartaric acid affected flow rate, dissolution time, and pH of the effervescent granule preparation.]]>
<![CDATA[Potensi interaksi obat nutrasetikal pada epilepsi anak ]]>
<![CDATA[Nialiana Endah Endriastuti]]>;
<![CDATA[Masita Wulandari Suryoputri]]>;
<![CDATA[Dewi Latifatul Ilma]]>;
<![CDATA[Tunggul Adi Purwonugroho]]>
<![CDATA[ Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo ]]>
Publisher : <![CDATA[Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia ]]>
Show Abstract
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DOI: 10.20884/1.api.2022.10.1.4352
<![CDATA[Background: The trend of using nutraceuticals in Indonesia increases every year. This study aims to describe nutraceuticals consumed in pediatrics with epilepsy as additional antiepileptic therapy and analyze their potential drug interactions. Methods: This research was a cross-sectional study with total sampling method which was carried out in the period of June to July 2020. Inclusion criteria were children with epilepsy aged 0-17 years who were members of the Indonesian Epilepsy Community, had a doctor's diagnosis of epilepsy, received oral antiepileptic medication, and took nutraceutical products/food supplements. Data were analyzed descriptively based on data obtained through electronic data filling sheets and interviews. Results: There were 106 participants from the Indonesian Epilepsy Community in total, with 14 children (13.2 %) using nutraceutical supplements. They were male (n=8; 57.1%), 2-12 years old (n=10; 71.4%), and good nutritional status (n=10; 71.4%). Most nutraceuticals consumed were dietary supplements containing vitamins (n=10; 71.4%). Of the eight potential drug interactions identified, 25% (n=2) were significant interactions, and 75% (n=6) were minor interactions. The potential for major interactions occurred in administering nutraceutical products containing vitamin D with the antiepileptic drug phenytoin and phenobarbital. Conclusion: In this study, nutraceuticals and antiepileptic drugs had a little clinically meaningful interaction effect.]]>
<![CDATA[Psidium guajava leaves extract decreased leukocytes and lymphocytes count in Complete Freund's Adjuvant-induced arthritis rats ]]>
<![CDATA[Hanif Nasiatul Baroroh]]>;
<![CDATA[Rupa Lesty]]>;
<![CDATA[Esti Dyah Utami]]>;
<![CDATA[Nur Ayunie Zulkepli]]>
<![CDATA[ Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo ]]>
Publisher : <![CDATA[Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia ]]>
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DOI: 10.20884/1.api.2022.10.1.5789
<![CDATA[Background: Psidium guajava is one of the herbal plants that has demonstrated antioxidant and anti-inflammatory properties. Objective: This study aimed to determine the effect of P. guajava leaves extract on leukocytes and lymphocytes in rats. Methods: Fifty rats were divided into five groups. Complete Freund’s Adjuvant (CFA) was employed to generate an animal model of arthritis. Group I (arthritis control) received CMC Na, group II (positive control) received dexamethasone 3 mg/kg BW, and groups III-V received 250, 500, and 750 mg/kg BW of the ethanol extract of P. guajava leaves orally. Total leukocyte counts were calculated on days 13 and 29, and on day 29, the histological joints were inspected. Results: The P. guajava leaves extract decreased the number of lymphocytes and total leukocytes. Before and after treatment, the group receiving doses of 250 mg/kg BW and 750 mg/kg BW of the extract showed a significant decrease in leukocytes. With treatment of 250, 500, and 750 mg/kg BW of P. guajava leaves ethanol extract, the lymphocyte count was also reduced. The P. guajava leaves extract at 750 mg/kg body weight showed the greatest effectiveness in suppressing leukocytes and lymphocytes. Conclusion: The extract of P. guajava leaves has the potential to be developed as an anti-inflammatory for arthritis.]]>
<![CDATA[Antibacterial activity of Cassia alata stems ethanol extract against Staphylococcus aureus ]]>
<![CDATA[Ahmad Mahdi Mar'ie]]>;
<![CDATA[Irfan Zamzani]]>;
<![CDATA[Siti Nashihah]]>
<![CDATA[ Acta Pharmaciae Indonesia : Acta Pharm Indo Vol 10 No 1 (2022): Acta Pharmaciae Indonesia : Acta Pharm Indo ]]>
Publisher : <![CDATA[Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia ]]>
Show Abstract
|
Download Original
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Original Source
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Check in Google Scholar
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DOI: 10.20884/1.api.2022.10.1.5462
<![CDATA[Background: Cassia alata leaves, also known as petai cina or gelinggang in Indonesia, are commonly used to treat skin ailments. Objective: The purpose of this study is to test whether stem of C. alata has antibacterial activity against Staphylococcus aureus. Methods: C. alata stems were extracted using an ultrasound-assisted extraction method. For antibacterial activity, disc diffusion was used with extract concentrations of 25%, 50%, 75%, and 100%. Results: The inhibition zones of the ethanol extract of C. alata stems at 25%, 50%, and 75% concentrations were 17.6 mm, 21 mm, and 22.6 mm, respectively, with the highest inhibition zone at 100% concentration at 25 mm. Conclusion: The ethanolic extract of C. alata stems has a strong inhibitory effect on Staphylococcus aureus.]]>
